Kelley-Seegmiller syndrome or Lesch-Nyhan syndrome, two rare conditions in which your body either does not have the enzyme that regulates urate levels or does not have enough of that enzyme.Conditions that cause your cells to turn over rapidly, such as psoriasis, hemolytic anemia, or some cancers.Chronic kidney disease, a condition that develops when your kidneys are damaged and cannot filter blood the way they should.Metabolic syndrome, a name for a group of conditions that include high blood pressure, high blood sugar, abnormal cholesterol levels, and excess body fat around the waist.Some health conditions may increase your risk of developing gout, such as: Drinking beverages that have high-fructose corn syrup, such as soda.Eating foods that are rich in purines (usually from animal sources), a substance that breaks down into urate.Having high urate levels however, not everyone who has high levels develops gout.However, certain factors may increase your chances of developing gout, including: Researchers continue to study how genes and environmental factors contribute to a buildup of urate in your blood. However, when too little is removed, urate builds up in your blood and needle-shaped crystals form in your joints, causing inflammation that is experienced as gout flares that cause pain and swelling. Normally, urate passes out of your body in urine. When purines break down, they become urate. Urate comes from purines, which are found in your body’s tissues and many foods. However, not everyone with high urate levels develops gout. This leads to pain, swelling, redness, and changes in the movement and use of the affected joint. Gout happens when urate, a substance in your body, builds up and forms needle-shaped crystals in your joints. Some people with gout may be more likely to develop other conditions or complications, especially with the heart and kidneys. Tophi start out as painless however, over time, they can become painful and can cause bone and soft tissue damage and misshapen joints. A tophus is the buildup of needle-shaped crystals that cause hard lumps to form under the skin, in and around the joints and other organs. If gout is untreated over long periods of time, tophi can develop. However, over time, if left untreated, your flares may last longer and happen more often. Some people may have frequent flares, while others may not have another flare for years. Flares typically get better over a week or two, and in between, you usually don’t have symptoms. Gout flares usually occur in one joint and can be triggered by certain foods, alcohol, certain medications, physical trauma, or certain illnesses. In addition, your joint may feel swollen, red, warm, and stiff. Gout flares often start suddenly at night, and the intense pain may be bad enough to wake you up. Many people have their first flare of gout in one of their big toes, but it can also affect other joints in your body. The most common symptom of gout is pain in the affected joint. Many people avoid gout flares and can decrease the severity of their symptoms, and can even become gout free. With early diagnosis, treatment, and lifestyle changes, gout is one of the most controllable forms of arthritis. Proper treatment can prevent the development of tophi. ![]() Depending on their location, tophi can permanently damage your joints and other internal organs such as the kidneys. ![]() Tophi, a late stage of gout when crystals build up in the skin or other areas of the body.Interval or intercritical gout, which is the time between gout attacks when you do not have any symptoms.Gout flares, when you have an attack of intense pain and swelling in your joints. ![]()
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